Archive for the ‘Allergies’ Category

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Children, Allergies, Milk, Eggs

February 10, 2009

“Fewer Children Outgrowing Allergies to Milk, Eggs”
Quotes: “Not only do more kids have allergies, but fewer of them outgrow their allergies, and those who do, do so later than before.”
“We may be dealing with a different disease process than we did 20 years ago. Why this is happening we just don’t know.”
http://www.cbc.ca/cp/HealthScout/090126/6012602AU.html

(HealthDay News) – Childhood milk and egg allergies may be more persistent and harder to outgrow than they were a generation ago, U.S. researchers report.

In two studies from the Johns Hopkins Children’s Center, researchers followed more than 800 youngsters with milk allergy and almost 900 youngsters with egg allergy for more than 13 years.

They found that the allergies often persist well into the school years and beyond.

Earlier research suggested that about 75 per cent of children with milk allergy outgrew the allergy by age 3. But the Hopkins researchers found that only 20 per cent of children with milk allergy outgrew it by age 4, and 42 per cent outgrew it by age 8. By age 16, 79 per cent no longer had the allergy.

There were similar findings among the children with egg allergy. Only 4 per cent outgrew it by age 4, 37 per cent by age 10, and 68 per cent by age 16.

The studies were published in the November and December issues of the Journal of Allergy and Clinical Immunology.

“The bad news is that the prognosis for a child with a milk or egg allergy appears to be worse than it was 20 years ago,” lead investigator Dr. Robert Wood, head of allergy and immunology at Hopkins Children’s, said in a prepared statement. “Not only do more kids have allergies, but fewer of them outgrow their allergies, and those who do, do so later than before.”

The findings seem to confirm what many pediatricians have long suspected – that food allergies diagnosed in recent years behave more unpredictably and aggressively than food allergies in the past.

“We may be dealing with a different disease process than we did 20 years ago. Why this is happening we just don’t know,” Wood said.
More information:

The U.S. National Institute of Allergy and Infectious Diseases,
http://www3.niaid.nih.gov/topics/foodAllergy/understanding/whatIsIt.htm

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Phthalates and Allergies: Study

February 10, 2009

“Phthalates worsen skin allergies in newborn mice exposed through their mothers.”
The study showed that exposure to phthalates via mother’s milk caused increased allergic reactions in offspring. Phthalates, of course, are found almost everywhere in the environment, and have been linked to reproductive defects, among other problems.

Synopsis by Benson T. Akingbemi:

http://www.environmentalhealthnews.org/ehs/newscience/phthalte-exposure-raises-skin-allergies-in-mice

Newborn male mice exposed to a common phthalate plasticizer (DEHP) through their mothers developed more severe allergic skin reactions to allergens than unexposed mice.

Research with mice reveals that the phthalate DEHP can increase the severity of allergic reactions in young animals when they are exposed neonatally to the contaminant via their mother’s milk.

Rates of allergic skin conditions — called dermitits — are increasing in people. Generally, the skin becomes swollen, red and itchy after being exposed to an allergen. These new results may shed light on one of the drivers of this trend.

This study suggests that environmental chemicals like DEHP may increase the potency of reactions to allergens and thereby play a role in the development and/or enhancement of allergic diseases. According to the authors: “Our results support the novel hypothesis that maternal exposure to DEHP during neonatal periods via breast milk and/or infant formula may be responsible, at least in part, for the recent increase in atopic dermatitis in offspring.”

DEHP is added to plastics, usually to make them flexible. Because of its widespread use in polyvinyl plastics, it is found almost everywhere in the environment. The compound is present in some food packaging, many household products, soft plastic toys, auto upholstery and medical tubing/bags. Exposure occurs through food, water, air and medical procedures in which DEHP-containing products are used.  DEHP is a common contaminant of household dust, because it is commonly used in vinyl flooring and in the backing of carpets.

The chemical’s link to reproductive effects in lab animals — specifically infertility and male reproductive defects — has led the European Union, Canada and the state of California to ban DEHP in toys and infant products.

To expose the developing mice, researchers gave pregnant dams DEHP at 0.8, 4, 20 or 100 micrograms on days 0, 7 and 14 of pregnancy. To expose newborns, a different set of mothers was injected with DEHP at the same doses on days 1, 8 and 15 after birth. The researchers then injected mite allergen into the pups on treatment days 0, 2, 4, 7, 9, 11, 14 and 16. They measured ear thickness, determined disease symptoms (dryness and wounding) and evaluated tissues for signs and severity of a type of skin allergy that resembles eczema.

Dermatitis-like skin problems were worse in newborn mice exposed to 100 micrograms of  DEHP through their mothers but not in any of the mice that were exposed while in the womb.  The scientist who carried out the research proposed this unexpected pattern could result from the fact that fetal immunity is largely dependent upon the mother’s immune system.  After birth, the newborn is increasingly dependent upon proper development of its own immune system.  These results suggest that this development is adversely affected by DEHP.

Original study:  “Effects of Maternal Exposure to Di-(2-ethylhexyl) Phthalate during Fetal and/or Neonatal Periods on Atopic Dermatitis in Male Offspring”

Environmental Health Perspectives Volume 116, Number 9, September 2008

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Fresh scents, toxic secrets

February 9, 2009

[Fresh scents, toxic secrets - this should come as no surprise, but, again, it's good to have the scientific validation. Whatever could have made us think that covering up the odors of normal living with artificial chemicals was a good thing? Umm, I guess that would be millions of dollars in advertising by the chemical industry, laying a guilt trip on housekeepers: "better living through chemistry"... for the industry, that is. Note: for the original research, published by kind permission of the author, please go to our Chemical Research page. ]

Fresh scent may hide toxic secret

Innocuous-sounding ‘perfume’ in detergents, air fresheners made with dangerous chemicals

Wednesday, July 23, 2008

By LISA STIFFLER
P-I REPORTER

The scented fabric sheet makes your shirts and socks smell flowery fresh and clean. That plug-in air freshener fills your home with inviting fragrances of apple and cinnamon or a country garden.

But those common household items are potentially exposing your family and friends to dangerous chemicals, a University of Washington study has found.

Trouble is, you have no way of knowing it. Manufacturers of detergents, laundry sheets and air fresheners aren’t required to list all of their ingredients on their labels — or anywhere else. Laws protecting people from indoor air pollution from consumer products are limited.

When UW engineering professor Anne Steinemann analyzed of some of these popular items, she found 100 different volatile organic compounds measuring 300 parts per billion or more — some of which can be cancerous or cause harm to respiratory, reproductive, neurological and other organ systems.

Some of the chemicals are categorized as hazardous or toxic by federal regulatory agencies. But the labels tell a different story, naming only innocuous-sounding “perfume” or “biodegradable” contents.

“Consumers are breathing these chemicals,” she said. “No one is doing anything about it.”

Industry representatives say that isn’t so.

“Dr. Steinemann’s statement is misleading and disingenuous,” said Chris Cathcart, president of the Washington, D.C.-based Consumer Specialty Products Association, in a statement.

“Air fresheners, laundry products and other consumer specialty products are regulated under the Federal Hazardous Substances Act and subsequently have strict labeling requirements,” he said. “Companies producing products that are regulated under FHSA must name on the product label each component that contributes to the hazard.”

Table

Millions are spent annually to ensure that fragrances in the products are safe, according to a joint statement from the Fragrance Materials Association, which represents fragrance manufacturers, and the Research Institute for Fragrance Materials, which works closely with the association.

Ingredients are routinely tested, and chemicals that are considered dangerous are present at levels much too low to cause harm, according to the groups.

But there are numerous reports of people — particularly those with asthma, chemical sensitivities and allergies — having strong adverse reactions, researchers said.

That’s a problem when public restrooms in restaurants or airplanes use air fresheners, or when hotels wash towels and sheets in scented laundry supplies. And even when the concentrations are low in individual products, people are exposed to multiple sources on a daily basis.

Aileen Gagney, Asthma and Environmental Health Program manager with the American Lung Association in Seattle, herself an asthma sufferer, has a rule of thumb to help avoid exposure: “If it smells bad, it’s bad; if it smells good, it’s bad.”

But even that won’t always work.

According to Steinemann, even products labeled “unscented” sometimes contain a fragrance and a “masking” fragrance to make them odor-free.

People, Puget Sound at risk?

For Steinemann’s research, published Wednesday in Environmental Impact Assessment Review, she selected a top-selling item from six categories of products: dryer sheets, fabric softeners, detergents, and solid, spray and plug-in air fresheners.

Then she contracted with a lab to test the air around the items to identify the chemicals people could be breathing.

Ten of the 100 volatile organic compounds identified qualified under federal rules as toxic or hazardous, and three of those — 1,4-dioxane, acetaldehyde and chloromethane — are “hazardous air pollutants” considered unsafe to breathe at any concentration, according to the study.

The labels gave no indication that the irritating and potentially dangerous chemicals were present, so Steinemann checked the product’s Material Safety Data Sheets. These technical documents provide ingredient information for the safety of workers and emergency responders. They, too, disclosed little detail, mostly citing ingredients such as “essential oils” and “organic perfume.”

“It’s a reasonable expectation to think that laundry products and air fresheners would be free of chemicals that can cause cancer,” said Erika Schreder, a staff scientist with the Washington Toxics Coalition.

“But as this UW study shows, it’s disturbingly easy to find toxic chemicals in everyday products like these because companies don’t have to say what’s in their products.”

Cathcart, of the Consumer Specialty Products Association, said the information’s not on the package because the “chemicals are not present in the products at levels deemed hazardous under the law. Given the limited space on product labels, it is important to include the relevant information consumers need to make intelligent use, storage and disposal decisions.”

The threat isn’t limited to people. Steinemann and others worry that the chemicals in consumer products flow from homes to the outdoors.

“These chemicals get into our water systems and into Puget Sound,” she said. They are “extraordinarily hard to get out of the environment.”

Steinemann’s research was paid for using discretionary money awarded to her as a UW professor; she wanted to avoid any appearance of a conflict of interest. She has also submitted for publication a study that goes further to examine ingredients in cleaning and personal-care products.

Regulatory gaps

With fears growing over chemicals in consumer products — lead in toys, bisphenol A in plastic baby bottles, phthalates in shower curtains and cosmetics — environmentalists and health advocates are calling for stricter regulations of chemicals in everyday goods. They also want shoppers to have more readily accessible information.

Manufacturers and trade groups representing consumer products routinely counter that there’s plenty of testing and oversight from within the industries and from government regulations to ensure safety.

In the fragranced-products arena, they point to industry Web sites with information on product ingredients and suggest contacting companies with specific questions.

Critics maintain that’s not enough.

“There’s obviously a loophole,” said Michael Robinson-Dorn, a UW law professor who aided Steinemann’s research. “We regulate many of these chemicals in other circumstances, yet when they’re in products that we’re in contact with daily, in some cases, we don’t wind up finding out about them.”

He said the items can slip between regulatory cracks by falling into the jurisdiction of multiple government agencies, none taking ownership.

“Any time you have a product that is regulated by many different agencies, it’s easy for them not to react,” he said.

In the absence of strong laws, the marketplace is starting to regulate itself.

After the Natural Resources Defense Council last fall found troubling levels of phthalates — plasticizing chemicals that can potentially harm developing babies — in air fresheners, Walgreens pulled the products from its shelves.

Last month, NRDC and other environmental groups sued the Environmental Protection Agency to force manufacturers to test air freshener safety and label products with a full ingredient list.

Steinemann’s study could push the process along.

“Consumer demand for less-toxic products will encourage companies to reformulate their products,” she said. “This is a case where a little information could have a great public benefit.”

Details on chemical risks

http://seattlepi.nwsource.com/local/371779_toxicfragrance23.html

P-I reporter Lisa Stiffler can be reached at 206-448-8042 or lisastiffler@seattlepi.com. Read her blog on the environment at datelineearth.com.

© 1998-2008 Seattle Post-Intelligencer

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Toxins and the young: new standards needed

February 8, 2009

Researcher: New toxicant safety standards are needed to protect the young

http://www.physorg.com/news151688225.html

January 20th, 2009 By Susan Lang

New toxicant safety standards are needed to protect the young

(PhysOrg.com) — In an invited, peer-reviewed journal article on how prenatal exposure to toxic substances are linked to a host of diseases in later life — from atherosclerosis to cancer — a Cornell toxicologist calls for changing how safety testing is done to better protect infants and children.

Safety testing for environmental chemicals and drugs is routinely conducted on adults, said Rodney R. Dietert, professor of immunotoxicology at the College of Veterinary Medicine, which is hardly relevant for young children or children in utero.

“The developing immune system is more sensitive to toxicants than that of the adult and in ways that cannot be readily predicted by adult safety testing,” said Dietert, whose perspective piece on developmental immunotoxicology (DIT) is the cover story of the January issue (22:1) of the American Chemical Society’s Chemical Research in Toxicology.

“Yet, many chronic diseases that have been increasing in incidence — including childhood asthma and allergies, autism, childhood leukemia, type 1 diabetes, celiac disease, rheumatoid arthritis and lupus — are associated with early life environmental exposures, and they all also have immune dysfunction in common.”

Dietert, who has been studying for more than a decade how toxic substances affect the developing immune system, stresses the need to focus more attention on identifying environmental factors that can damage the immune system during prenatal, infant and juvenile development. Protecting the immature immune systems could not only extend quality of life during adulthood, but also reduce future health care needs.

“The maturing immune system is a vulnerable target for toxicants as it progresses through a series of novel prenatal and perinatal events that are critical for later-life host defense against a wide array of diseases,” said Dietert. “When it is disrupted by exposure to chemicals, all too often the outcome takes the form of persistent immune dysfunction or misregulation. For this reason, the health risks of exposure to toxicants are significantly greater in early life.”

Because DIT is linked to a majority of the most significant childhood chronic diseases, he added, “safety testing for DIT is a pivotal issue in the protection of children’s health.”

Provided by Cornell University

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Your Daily Dose

February 6, 2009

Several references on chemicals in our daily lives, whether we want them or not – cosmetics, detergents, plastics, scented products – many with neurotoxins, affecting human and environmental health in a variety of ways, including reproductive health.

“Canada Declares Chemicals Used in Cosmetics to be Toxics”
Quote: “The Canadian government today declared two chemicals used in lipstick and other personal care products to be toxic to the environment” [January 30, 2009]
http://www.ens-newswire.com/ens/jan2009/2009-01-30-01.asp

“Home Sick”
Book reviews in The Washington Post of Poisoned Profits: The Toxic Assault on Our Children, by Philip and Alice Shabecoff, and The Body Toxic: How the Hazardous Chemistry of Everyday Things Threatens Our Health and Well-being, by Nena Baker. Reviews by Seth Shulman.
Quotes: “The Shabecoffs deserve credit for forcefully urging the issue of our children’s environmental health onto the national agenda where it surely belongs.”
“Baker has written an illuminating, consumer-oriented book that sifts through some of the latest findings about the dangers of everyday chemicals.”
http://www.washingtonpost.com/wp-dyn/content/article/2008/09/04/AR2008090402404_pf.html
And reviews of the same books in the San Francisco Chronicle by a staff member of the San Francisco Medical Society:
http://www.sfgate.com/cgi-bin/article.cgi?f=/c/a/2008/10/10/RVA813D4LD.DTL

“Neurotoxin In Everyday Household Items”
Quotes: “Everyday household things could be doing our kids harm and we don’t even really understand what they can do yet,” said mother Christi Williams.
“Many of these chemicals are linked not just to the petro-chemical industry but to the toxins that infuse our daily lives: solvents, detergents, cosmetics, herbicides, pesticides – plastics. As the Commonweal Biomonitoring Resource Center concluded in its recent study of chemical contamination: ‘much of our exposure may be from products we have assumed to be safe for use.’ “
http://wcco.com/local/neurotoxin.household.items.2.811758.html

“This toxic life”
Sarnia’s “chemical valley”, Aamjiwnaang, gender-bending, carcinogens, asthma – warning us of where we’re all headed: “where the environment is concerned we all live downstream”.
Quotes: “‘Millions of tons of reproductive toxins are spewed out by these facilities year in, year out. Their effect on animal life has been well documented throughout the Great Lakes. To think these poisons would affect everything else and not the human population is bizarre.’ ”
“Critics predict that in 10 years the fallout from the petro-chemical and plastics plague will rank with tobacco and pesticides as a major global public health issue.”
http://www.newint.org/features/2008/09/01/keynote-plastic/

“The Health Hazards of ‘Fragrances’: Toxic chemicals found in common scented laundry products, air fresheners“
Quote: “A University of Washington study of top-selling laundry products and air fresheners found the products emitted dozens of different chemicals.”
Each of the products tested gave off at least one chemical Federally classified as toxic or hazardous, yet none – repeat, none – of them listed those chemicals on their labels.
http://www.cbsnews.com/stories/2008/07/25/health/webmd/main4295506.shtml
And a link to more info on the major researcher, Dr. Anne Steinemann, http://water.washington.edu/Outreach/Events/SpecialEvents/oslsAS.html

“Essential vs Fragrance Oils: The Hazards of Scents”

Quote: “95% of the chemicals found in these oils are synthetic compounds derived from petroleum, and include chemicals such as benzene derivatives, aldehydes, and others capable of causing cancer, birth defects, central nervous system disorders (CNS) and allergic reactions. Today, fragrances are marketed to an unsuspecting public who think that these scents are natural.”
Phthalate esters, hormone disruption, neurological and respiratory effects – and if that’s not enough, waste water treatment facilities do not remove fragrance chemicals, and they have been found in our drinking water… not to mention lakes, rivers and groundwater.
http://www.hans.org/enews/issue/90#a5
http://www.herc.org/news/perfume/risks.htm
http://www.ourlittleplace.com/perfume.html

“Plasticizer related to lower hormone levels in men”
Synopsis: http://www.environmentalhealthnews.org/ehs/newscience/phthalates-and-mens-lower-hormone-levels
Quotes: “ Adult men with average amounts of phthalates in their urine had lower levels of two important hormones — testosterone and estrogen — in their blood. The hormones are necessary for normal sperm production and function.”
“This is the first study to show a relationship between phthalate levels and hormone levels in adult men.”
The original study: “Urinary Metabolites of di(2-ethylhexyl) phthalate Are Associated with Decreased Steroid Hormone Levels in Adult Men”
http://www.andrologyjournal.org/cgi/content/abstract/jandrol.108.006403v1

“Common Chemicals May Affect Fertility”
Quote: “Exposure to a type of chemical found in everyday items such as clothing, carpets, and food packaging may be adversely affecting women’s fertility, delaying the time it takes them to become pregnant, according to a new study. In the study, the higher the concentrations of these chemicals — called perfluorinated chemicals (PFCs) — in the women’s blood samples, the more likely the women were to take more than 12 months to get pregnant.”
http://www.webmd.com/infertility-and-reproduction/news/20090128/common-chemicals-may-affect-fertility?print=true
For a PDF of the study, “Maternal levels of perfluorinated chemicals and subfecundity”, go here: http://humrep.oxfordjournals.org/cgi/reprint/den490v1

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Phthalates, POPs, Kids

February 6, 2009

“Study finds moms share phthalates with their babies”
Synopsis: http://www.environmentalhealthnews.org/ehs/newscience/phthalates-in-moms-and-babies/
Quote: “In the first study of its kind, researchers in Taiwan find that phthalates can pass from  pregnant women to their unborn babies and affect reproductive development in their daughters.”
The original study: “Association between prenatal exposure to phthalates and the health of newborns”
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V7X-4T1SFM6-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d1af14ee9a35791ccc935faecfd35b05

“Phthalates worsen skin allergies in newborn mice exposed through their mothers.”
The study showed that exposure to phthalates via mother’s milk caused increased allergic reactions in offspring. Phthalates, of course, are found almost everywhere in the environment, and have been linked to reproductive defects, among other problems.
Environmental Health Perspectives 116:11

“Fewer Children Outgrowing Allergies to Milk, Eggs”
Quotes: “Not only do more kids have allergies, but fewer of them outgrow their allergies, and those who do, do so later than before.”
“We may be dealing with a different disease process than we did 20 years ago. Why this is happening we just don’t know.”
http://www.cbc.ca/cp/HealthScout/090126/6012602AU.html
More information:
The U.S. National Institute of Allergy and Infectious Diseases,
http://www3.niaid.nih.gov/topics/foodAllergy/understanding/whatIsIt.htm

“Lawmakers Agree to Ban Toxins in Children’s Items” (US)
A ban on phthalates, significant in its own right but also because: “It also signals an important crack in the chemical industry’s ability to fend off federal regulation and suggests that the landscape may be shifting to favor consumers.”
http://www.washingtonpost.com/wp-dyn/content/article/2008/07/28/AR2008072802586_pf.html

“Perfumed Mother’s Milk”
Study showing that chemicals from soaps and personal care products gets passed on to children – as well as PCBs and pesticides.
Science News, Aug. 8, 2008.
http://www.precaution.org/lib/08/ht080814.htm

“Women warned not to wear perfume during pregnancy”

Quote: “Pregnant women have been advised to avoid using perfumes or scented body creams after research suggested the products can cause unborn boys to suffer infertility or cancer in later life.”
http://scotlandonsunday.scotsman.com/health/Women-warned–not-to.4443471.jp

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Black mold

June 25, 2008

In a New Scientist article, in response to a question regarding “dreaded black mold”, we read the following from Brian Flannigan, Department of Biological Sciences, Heriot-Watt University, Edinburgh, UK. Previous responses addressed Aspergillus Niger, considered “a major source of allergenic disease in that it produces carcinogenic aerosols”.

“The most common dark molds in growths on bathroom and other damp walls are likely to be species of Cladosporium, with Aureobasidium, Phoma, and Ulocladium thrown in for good measure. Even green species of Aspergillus and Penicillium can look black when soaked.

The situation is much the same in mainland Europe, so it is likely that it will not be very different in Northumberland or Surrey, unless the bathrooms there come closer than most British bathrooms to providing the subtropical and tropical climates that favor A. Niger.

A really black fungus is about 15 percent of houses in Scotland with mold problems is Stachybotrys aira. Wallpaper, jute carpet backing, and the cardboard wrapper of gypsum board all provide ideal cellulosic substrates on which it may thrive in damp conditions. This type of mold may present the greatest hazard of any to the health of occupants of moldy buildings. Its airborne spores are allergenic and powerfully toxigenic. Its toxins inhibit protein synthesis, and are immunosuppressive, an irritant, and hemorrhagic.

It is well known that fodder contaminated by Stachybotrys can kill horses, and it is also harmful to the stable hands. Currently, this mold is of particular concern in North America, where it has been implicated in episodes of building-related illness ranging from chronic fatigue syndrome in adults to fatal pulmonary hemosiderosis in infants. Consequently it has been the subject of lawsuits (one for the sum of $40 million) against builders and employers.”

Recommendation: if you see black mold, call a professional. Have it sampled, have it tested, have it dealt with – all under containment. When it comes to mold, black=bad, and it could be deadly.